Thomas Dawson (Nick Tate), the boss of the super thief group The Works, is about to retire. At the dinner party for selecting the successor, a group of unidentified thugs suddenly broke in and started killing people. Thomas was kidnapped by Mike Lee (Jerry Yan), who has always been at odds with Lupin (Oguri Shun), and was later killed by his accomplices. A year later, Lupin III was captured by Inspector Zenigata (Tadanobu Asano) after being plotted against by Fujiko Mine (Aisa Kuroki). Zenigata revealed to him the whereabouts of Mike and the transaction information between the necklace of light in Mike's hand and the crimson ruby in the hand of the underworld emperor Pramuk (Nirut Sirichanya). Lupin, who cleverly escaped, gathered Fujiko, Daisuke Jigen (Tetsuji Tamayama), Goemon Ishikawa (Tsuyoshi Ayano), Pierre (Jin Jun) and others, preparing to steal both of Cleopatra's scarlet hearts. A fierce battle between thieves and attackers begins...