Lawrence Talbot (Benicio Del Toro) has been away from home for many years and has little contact with his family due to the sad memories of his childhood. One day, Lawrence, who was performing in London, was found by his younger brother Benjamin's fiancée Gwen Conlever (Emily Blunt). Conlever told Lawrence the news of Benjamin's tragic death and asked him to return to his hometown Black Wilderness to investigate. Lawrence returned to the place where he lived in his childhood. This trip, he not only wanted to find out the murderer who killed his brother, but also hoped to uncover the truth about his mother's tragic death in his father's arms. The Black Wilderness, which was like a paradise in memory, fell into panic because of the successive attacks and deaths, and there were many different opinions about the monster that appeared on the night of the full moon. During the investigation, Lawrence finally saw the legendary monster-werewolf with his own eyes. In the process of chasing the werewolf, Lawrence was unfortunately bitten. After recovering from his injury, Lawrence felt changes starting to occur in his body. The legend that one would turn into a werewolf after being bitten by a werewolf came true for Lawrence...