19 years later, Dr. Indiana Jones (Harrison Ford) sets out again to return the lost crystal skull of the Kingdom of Ector to its original place. According to legend, those who return the sacred object will be given great power. Before Jones's old friend Oakes discovered the crystal skull, all this was just a legend. But Oakes somehow lost his mind and fell into the hands of the Soviet special forces. The cold female spy Irena (Cate Blanchett) who led the team was deeply fascinated by the so-called mysterious power. She forced Jones and his team to go to the Amazon Basin with them to find the lost golden city of Ector. In the dense jungle of Peru, Jones and others fought a hearty battle with the Soviet army, accompanied by deadly threats such as swamps, man-eating ants, and primitive indigenous attacks. When they went through numerous hardships and finally stepped into the secret room, the most bizarre scene in the world appeared...