Dr. Richard (Ioan Gruffudd)'s scientific dream is about to come true! He will fly to the center of the cosmic storm to uncover the code of human genes. Also traveling with him are project sponsor von Doom (Julian McMahon), astronaut Ben Grimm (Michael Chiklis), Dr. Richard's ex-girlfriend Sue Stone (Jessica Alba) and her brother Johnny Stone (Chris Evans). Unexpectedly, when the spacecraft approached the center of the storm, due to a miscalculation, the spacecraft was swallowed by cosmic rays! After escaping the disaster and returning to Earth, the genes of the team members mutated due to the influence of cosmic rays, and they have different superpowers. Richard, Sue, Johnny and Ben formed the "Fantastic Four", using the superpowers given by cosmic rays to fight against dark forces and help the world. After Doom gained superpowers, he transformed into "Dr. Steel Eye of Destruction" and is implementing his evil plan. The Fantastic Four are on the move!