The story is set against the backdrop of the global spread of the "Simian Flu" virus, with humans on the verge of destruction, while apes that have evolved into advanced intelligent creatures have become the kings at the top of the food chain. As time passes, the tyrannical ape leader, Cesar (Kevin Durand), builds the first empire in the history of the apes in the ruins - the "Planet of the Apes", which is the dawn of the birth of a new world order. The appearance of the mysterious human girl Nova (Freya Allan) aroused Cesar's vigilance. She seems to hold a huge secret, which not only concerns the survival of mankind, but may even subvert the entire "Planet of the Apes" again. Nova, who was forced to flee, intersects with the fate of the young ape Noah (Owen Teague) in the process of evading Cesar's army, revealing an adventurous journey.