Richard (Paul Giamatti) and Rachel (Kathryn Hahn) are suffering from infertility. The couple devotes themselves to assisted reproduction and adoption arrangements, sinking deeper and deeper into this narrow field while working hard to maintain their marriage. They tried in vitro fertilization, which was severely affected emotionally and financially. As they were about to enter the end of middle age and felt that they had reached the end of their rope, Sadie (Kayleigh Carter), a recent college dropout, appeared and re-entered their lives, and everything finally began to look up...