In order to obtain more Smurf essence, the evil wizard Gargamel (Hank Azaria) created two mischievous gray elves, Vexie (voiced by Christina Ricci) and Hekus (voiced by JB Smoove). However, he could not extract essence from the gray elves, so Gargamel sent Vexie to sneak into the forest and kidnap Smurfette (voiced by Katy Perry), who was about to celebrate her birthday, hoping to torture her to find out the secret of Papa Smurf (voiced by Jonathan Winters) turning her blue. In order to rescue Smurfette, Papa Smurf led Clumsy (voiced by Anton Yelchin), Disgusted (voiced by George Lopez), and Float (voiced by Christina Ricci) to return to the human world, and with the help of their human friends, they launched a rescue operation for Smurfette...