In 1925, in the Yang family of Liling, Hunan, the eldest son Yang Liren (Huang Zhizhong) was a teacher, thoughtful and resourceful; the only daughter Yang Lihua (Zhang Heng) has been studying since childhood, has an independent personality and is a representative of the new woman; the youngest son Yang Liqing (Sun Honglei) is stubborn and rebellious, but brave and upright. Liren was initially influenced by revolutionary ideas and joined the Kuomintang. Later, he entered the Huangpu Military Academy as an instructor. Liqing also happened to enter the Huangpu Military Academy to study at this time and met the family of Qu En (Sun Chun), a Communist Party member of Huangpu Political Instructor. Liqing not only regarded Qu En as a spiritual mentor, but also fell in love with Qu En's sister Qu Xia (Ke Lan). The relationship between the Kuomintang and the Communist Party continued to change, and the fate of the three siblings suddenly changed. Liqing and Liren turned against each other. In that turbulent era, where will the blood-thicker-than-water family affection, revolutionary ideals and pure love go? "The Road of Life is Long and Changing" won the first prize of the 28th China TV Drama "Flying Apsaras Award", the 15th Asian Television Awards, the 16th Shanghai TV Festival Best TV Series Gold Award and many other awards.