In the 1930s, South China Medical University welcomed new students. Xia Mengqian (played by Wen Xin) and Fang Huiru (played by Zhao Dona), good sisters from wealthy families, were assigned to the closed dormitory 415, which was said to be haunted and had caused deaths. They were also accompanied by Wang Ziqiao (played by Zhao Meitong), who was diligent in studying divination, and He Qiulan (played by Wang Qianyi), who was noble, cold and self-righteous. Campus horror legends, combined with romantic and beautiful youthful love, make the girls' campus life full of different fun. However, everything took a sharp turn for the worse. Mengqian accidentally discovered Qiulan's romantic affair, and the latter committed suicide by jumping off a building due to an anonymous report letter. Not long after, Ziqiao also died. The fresh campus life was overshadowed by terror. Behind a series of terrorist incidents, the evil and sinister conspiracy quietly surfaced...