The film is adapted from Alan Green's novel "Dark Area" published in 2001. The starring Bradley Cooper was awarded the title of the world's sexiest man in 2011. The decadent Eddie Morley (Bradley Cooper) is a writer who has lost his job and lacks inspiration. His former brother-in-law, who has not been in contact for a long time, gave him a drug that is in the experimental stage-NZT. After taking it once, Eddie found that he was energetic, clear-minded, and agile. He could even reorganize and sort out some details and information that were not easy to notice in an instant and draw inferences. When he went to find his brother-in-law again, he found that he had been murdered, the house was in a mess, and a group of killers were chasing him. Eddie, who escaped from death, finally discovered that this new drug called NZT can enable people to use 100% of their brains. With the help of NZT, Eddie regained inspiration and entered the upper class, but his great success also had fatal effects: physical discomfort and uncontrolled emotions. At this time, Eddie can no longer leave the drug, which makes him enter a dark realm, and the killer is also watching him in the dark...