In the 15th year of Chongzhen in the Ming Dynasty, the country was in trouble both internally and externally. General Sun Chuanting (played by Dai Liren) was ordered to bring his wife Feng (played by Feng Bo) to Tongguan to resist Li Zicheng's army. At the same time, the itinerant doctor Wu Youke (played by Feng Yuanzheng) came to Tongguan to visit his master, Zhao Chuan (played by Qian Xuege), the head of the pharmacy, with the heart of saving the world. Faced with a powerful enemy, the soldiers in Sun Chuanting's army contracted a strange disease. At the same time, they had to face the urging of Emperor Chongzhen (played by Yu Shaoqun) to send troops and the selfish money-making of Tongguan gentry Gu Qingyuan (played by Ma Jingwu). Zhao Chuan died because of his ineffective rescue. Wu Youke stepped forward in times of crisis and sympathized with Sun Chuanting with his unusual treatment methods. In the end, the plague was finally brought under control, but Wu Youke and Sun Chuanting could not predict whether the country's illness could be cured by the war. The theme song of this film is sung by BossaNova Queen Lisa Ono. This is the first time that Lisa Ono has performed her own song in Chinese.