A mysterious virus broke out at the Arctic Biosystems Research Base in the polar region, causing a tragedy in which three people were infected and two died. In order to find out the cause of the virus and prevent more than one hundred other scientists from various countries from being in danger, the US Centers for Disease Control and Prevention, at the request of the military, sent four elites including Alan Farragut (Billy Campbell), Julia Walker (Kyra Zagorsky), Sarah Jordan (Jordan Hayes) and Doreen Boyle (Catherine Lemieux) to the Arctic. Peter (Neil Napier), the survivor of the three, is Alan's brother. His brother and his wife Julia divorced because of an absurd incident. Although the group was warmly received by Dr. Hata (Hiroyuki Sanada), there seemed to be hidden secrets in the base. And with the sudden disappearance of the extremely weak Peter, Alan's investigation began to develop in an unpredictable direction...