In the vast outer space, the blue earth contrasts sharply with the bottomless and dark universe. A space station belonging to the United States, several astronauts are walking in space and doing routine inspections on their satellites. Dr. Ryan Stone (Sandra Bullock), who has just been in space, checks every component in an orderly manner with the assistance of experienced astronaut Matt Kowalski (George Clooney). This is Kowalski's last flight before retirement, and he is humorous and lively in the team's atmosphere. At this moment, horrifying news came from the Houston headquarters. Not long ago, a Russian satellite that was about to be abandoned was destroyed by a missile. The fragments scattered in the Earth's orbit at a speed faster than a bullet, and accidentally hit other satellites, causing a chain reaction to create new fragments. Ryan and his party were severely hit by the fragments, some of their companions died, and she and Kowalski lost control and fell into the depths of the universe. The two survivors had to trust each other and try their best to move towards their homeland...