The huge "Academy City" located in western Tokyo. In this city with a total population of 2.3 million, about 80% of which are students, a special course for developing superpowers is implemented, and students' abilities are evaluated in six stages from "no ability Level 0" to "superpower Level 5". High school student Kamijou Touma is also one of the students living in Academy City. He was evaluated as "no ability" and failed to pass the exam because of the power hidden in his right hand - "Imagine Breaker" which can eliminate even the blessing of God as long as it is supernatural power, and lived a life full of misfortune. Kamijou's student life has undergone a huge change due to the pure white nun who fell from the sky at the beginning of summer vacation. Since meeting her who escaped from the "magic" world - "Index of a Forbidden Books", Kamijou has been involved in various incidents. In the process of thrillingly solving the incidents of both sides, he gradually expands his interpersonal relationships while leading the "science" side of Academy City and the "magic" side related to Index. After that, the Roman Orthodox Church, the largest sect of the Christian religion on the magic side, finally noticed Kamijou's existence... As if responding to the magic side, the science side of the Academy City also made some moves. But there are also people who continue to fight against the world's trend that is gradually becoming hostile. Those "heroes" whose fate has been greatly changed by being connected to Kamijou. They stand up and confront the world. Just like Kamijou Touma did. When science and magic intertwine for the third time, the story will be greatly advanced! !