A heart-stealing demon suddenly appeared in the capital, frequently committing murders and then taking away the heart. Yang Yuxuan was ordered to catch the murderer, but unfortunately died in a fire to protect Zhu Yipin. Zhu Yipin was extremely sad and vowed to avenge Yang Yuxuan. The emperor suddenly fell ill and looked for a miracle doctor from the whole society. Zhu Yipin suspected that the heart-stealing demon was hiding in the palace, so he resolutely took off the imperial edict and entered the palace. After a hard investigation, Zhu Yipin found that the imperial physician Zheng Zainong was the heart-stealing demon, but unfortunately he escaped in the chaos. In the process of looking for Zheng Zainong, Zhu Yipin discovered that Prince Ning intended to rebel. For this reason, he and his colleagues in the medical clinic were repeatedly involved in vicious and dangerous situations, but they relied on tacit cooperation and increasingly improved reasoning ability to successfully solve the case again and again, and also revealed Prince Ning's conspiracy bit by bit. In the end, they went deep into the enemy's lair and once again successfully prevented Prince Ning's rebellion and protected the peace of the country.