The super virus "Kimira" and antibiotics were stolen by the terrorist leader Sean Ambrose (Dougray Scott) during transportation. Ethan Hunt (Tom Cruise) led his IMF team to accept the CIA's mission to retrieve the virus. This time, Ethan Hunt found a female thief Nyah Nordoff-Hall (Thandie Newton) as a partner, who was Sean Ambrose's ex-girlfriend. While Ethan Hunt gained Nyah's trust, the two also secretly fell in love. However, in order to complete the mission, Ethan Hunt had to arrange for Nyah to go undercover with Sean Ambrose. Nyah finally found out the pharmaceutical factory where the virus was located. Ethan Hunt, who received the intelligence, went to the pharmaceutical factory to prepare to destroy the virus; on the other hand, Sean Ambrose had already noticed the real purpose of Nyah returning to his side, and organized people to wait for Ethan Hunt to fall into the trap at the pharmaceutical factory. In the fierce fight, Nyah injected the virus into herself in order to help Ethan Hunt complete the task. Only by injecting antibiotics into Nyah's body within 20 hours can her life be saved. Ethan Hunt will face an impossible task again.