In 1999, a huge meteorite fell on the earth and robbed the entire ocean. At the same time, extraterrestrial creatures WORM began to multiply all over the world. In order to fight against WORM, which dominated a wide area in an instant, humans established the anti-WORM organization ZECT. ZECT developed the Kamen Rider system and put it into the battlefield to fight against WORM. Time spent in this war for seven years. In 2006, on this desertified earth, some members of ZECT formed an independent group NEOZECT because they were dissatisfied with the constraints of the organization, and ZECT also began to purge this group of traitors. At this time, the appearance of Tendou Souji, that is, the Kamen Rider KABUTO, greatly changed the situation of the war. ZECT headquarters learned that a giant ice comet was approaching the earth, so they proposed the "Sky Ladder Project", setting up a giant CLOCKUP machine in the space station in the atmosphere to create a transfer space to pull the comet to the earth and create a huge source of water. Through this plan, ZECT's power will become more and more powerful, enough to dominate the earth. ZECT uses the orbital elevator connecting the earth and the universe to launch the "Sky Ladder Project", and NEOZECT, who learned of this information from Tiandao, also decided to seize this plan to suppress ZECT from continuing to increase its power. ZECT fighters Yamato Tetsuki and Yagura Sou fight for the organization; NEOZECT fighters Oda Hidenari and Kazama Daisuke fight for freedom; Kaga Misaki fights for his beloved Hiyori, and there is Tendo Souji whose purpose is completely unknown; and the mysterious Golden Masked Rider. In the vortex of everyone's intertwined thoughts, the battle of the Masked Riders has extended to the vast universe...