In the fall of 2010, WHO official Eiko Kobayashi (Rei Dan) traveled with the team to the Philippines to eradicate bird flu. The epidemic was quickly brought under control, but some infected people still left the epidemic area privately... The following year, a high fever patient admitted by doctor Tsuyoshi Matsuoka (Satoshi Tsumabuki) in a municipal hospital in Tokyo took a turn for the worse, coughing up blood and dying. The patient's family and some doctors also fell ill due to infection. At the same time, bird flu virus was detected in a chicken farm in the suburbs, and the peaceful life of the farm owner Kamisao and his daughter (Chizuru Ikewaki) was broken. Eiko Kobayashi was ordered to guide the epidemic prevention here, and his old acquaintance Matsuoka served as his assistant. The epidemic spread rapidly, with the number of deaths reaching 2,000 within a month. Panic broke out in various places, attracting international attention, and the government quickly blocked the epidemic area. Matsuoka accidentally learned that the source of the virus might be somewhere else. The test results sent back from abroad supported his judgment, and Matsuoka decided to go abroad to find the source of the disease. In the unprecedented epidemic, Matsuoka, Kobayashi and Shen Cang will each face the test of their own choices.