Audrey (Jennifer Aniston) and Nick (Adam Sandler) have been married for seven years. Feeling the "seven-year itch", the couple decided to use a trip to repair their relationship and rekindle their love. On the plane, the couple met a millionaire, Murcon (Terence Stamp), who enthusiastically invited them to join his social circle and go on vacation to his mansion in Europe. However, what Audrey and Nick did not expect was that a murder had actually occurred in the mansion, and as "uninvited guests", they soon became the biggest suspects. It was not until then that the two realized that perhaps they had broken into a trap and became scapegoats for the murderer.