The story takes place in an isolated village, Waichang Village. For many years, the village has maintained the most ancient funeral method, burial. This provides a unique and good environment for the generation of a monster called "Shiki". Shiki, a kind of zombie, is strong but afraid of sunlight. It lives on sucking human blood and expands its strength by turning ordinary humans into Shiki. They have only one goal, which is to completely occupy Waichang Village. Strange things are happening secretly in various parts of the village, and no one has linked them together. When fear breaks out, it is too late. Yuuki Natsuno (voiced by Uchiyama Koki) is the first person to discover the existence of Shiki. When he is attacked by Shiki, he becomes a subspecies of Shiki, "Werewolf". In addition to being physically stronger than ordinary people, Werewolf is no different from humans. Therefore, Werewolf has become the only existence that can compete with Shiki. In this small village, surrounded by fear and blood, a brutal war is about to unfold between the leader of the ghouls, Kirifuki Sako (voiced by Aoi Yuuki), and the leader of the werewolves, Natsuno Yuuki, and between the simple villagers and the bloodthirsty monsters.