The protagonist, Daisuke Yamamoto, was stranded in the Amazon River in South America when he was young due to a plane crash, but the miracle is that he was able to live on his own and trained a body of steel in the forest. But at this time, the evil organization, Kido, wanted to use the ancient Inca civilization to conquer the world. In order to fight Kido, the inheritor and guardian of the ancient Inca civilization, Elder Bago, performed surgery on Daisuke Yamamoto and implanted the Inca secret treasure Jiji wristband in his left arm, transforming him into a mysterious warrior lizard-transformed Kamen Rider Amazon. Daisuke then returned to Japan to find out his life experience, and then began his destiny to fight against the Kido organization led by the Ten-Faced Demon who invaded Japan.