The experience of mutation at Gaohua University is always repeated, and the military's wanted list is also lingering in his mind. Scientist Bruce Banner (Edward Norton) is in such a nightmare in Brazil, while controlling the abnormalities caused by gamma radiation in his body, and trying to find a solution with Mr. Blue in New York. One day, he accidentally cut his finger in the soda production plant, and blood dripped into the soda bottle. The soda sold to the United States exposed his whereabouts. The US military exhausted its ability to hunt him down, and also found the British Thunderbolt General Emil Blonsky (Tim Roth) who was eager to win. Bruce, who was forced into a desperate situation, turned into the Hulk, and Emil and other soldiers were shocked. In order to capture Bruce personally, Emil suggested injecting himself with a sample that could cause genetic mutation. Bruce met his old girlfriend Betty Ross (Liv Tyler) while hiding in the United States. Betty stood by his side without hesitation, and at the same time found that she had the power to stabilize the Hulk in his body. Over there, Emil has been blinded by his desire to win. His provocation, coupled with the US military's determination to use Bruce's superpowers to commit brutal acts, has made a war inevitable.