In Locked Up Boy, a boy (Charlie Shotwell) is forced to live a life of isolation and decay due to an unknown illness. After exhausting all other options, his parents (Kelly Reilly and Max Martini) entrust their son’s life to a doctor (Lili Taylor). The cutting-edge treatments that the doctor is experimenting with in her clean house facility may be Eli’s last hope. As Eli undergoes the drastic treatments that could potentially cure him, he begins to feel anxious, and his experiences make him question who he can trust and what is really hidden in this house.