Dean (Jensen Ackles) and Sam (Jared Padalecki) are two brothers who were born in the Winchester family. They carry in their blood the inherent responsibility of becoming "hunters" to deal with demons and supernatural forces that harm humanity. 22 years ago, their mother encountered a demon, so their father John (Jeffrey Dean Morgan) has been trying to hunt down demons for many years while training the two brothers to become excellent hunters. However, compared to his brother Dean's enthusiasm for "hunting", his younger brother Sam obviously loves ordinary life more. He entered Stanford University, has a beautiful girlfriend, and is determined to break away from his weird family. Unexpectedly, his father disappeared during a hunting activity, and Dean could only call on his brother for help. Sam was reluctant at first, but as the investigation deepened, he found that the destined things could not be changed by his own strength at all...