Ten years have passed since the shocking Wittburgh murder. Sydney Prescott (Neve Campbell), the survivor of the murder, has experienced unimaginable pain and suffering. Now she has finally walked out of the shadow of the past. She wrote a book about the unbearable past, and her experience was made into a series of movies, which became popular all over the country. At the last stop of the national book signing, Sydney came to her hometown of Wittburgh. However, bad luck seemed to follow her. The night before, two young girls were killed by the ghost-faced killer at home, and a bloody knife was found in Sydney's car. Sheriff David (David Arquette) paid close attention to this, and he and his wife Gail (Courteney Cox) actively tracked down the real murderer. At the same time, Sydney's cousin Jill (Emma Roberts) and her friends also received death calls from strangers. A new round of massacres began, and bloody winds were inevitable...