Seattle Grace Hospital welcomes a new batch of interns, Meredith Grey (Ellen Pompeo), Christina Yang (Sandra Oh), Isobel Stevens (Katherine Heigl), George Meili (TR Knight), Alex Carle (Justin Chambers), five medical school friends graduated at the same time, and they need to compete for the official seat of the residency with good performance. At the beginning of entering the hospital, Meredith collapsed to find that the man who had a one-night stand with her in the bar the night before was actually neurosurgeon Derek Sheber (Patrick Dempsey), and the entanglement between the two began; Christina attracted the attention of thoracic surgeon Preston Burke, because they were equally arrogant and ambitious; George secretly loved Meredith; the beautiful Isobel immediately spread rumors, and the one-year internship was destined to be full of high-intensity pressure competition and hormones...