On the streets of New Orleans, word begins to spread about a mysterious new pill that unlocks superpowers unique to each user. But the problem is: no one knows what will happen after taking the drug before taking it. Some people will evolve bulletproof skin, invisibility, and super strength, while many others will exhibit more deadly reactions. However, when the pill escalates crime in the city to dangerous levels, the local police (Joseph Gordon-Levitt) teams up with a teenage vendor (Dominique Fishback) and a former soldier who swore personal revenge (Jamie Foxx) to take the risk of taking the pill to track down and stop the team that made the pill.