Five years have passed since then. Amazons have been almost exterminated, and the world is at peace. However, the phenomenon of ordinary people infected by Amazon cells becoming Amazons continues to expand, so the government has formed a new organization, 4C, to secretly exterminate Amazonized humans. Among them, Chitsuba, a boy who was raised by Amazons in his childhood, transforms into Kamen Rider Amazon Neo to fight Amazons. But in front of him, driven by his innate cannibalistic impulse, appears a girl, Yu, who transforms into a crow Amazon and fights as a biological weapon. For this Yu, for the first time, he does not have the thought of "wanting to eat" and is attracted to her. Yu's true identity is an Amazon that was resurrected as a Sigma type after being killed by his Amazonized father.