Alchemy, a science based on the principle of equivalent exchange, understands, decomposes, and reconstructs matter, turning one item into another. However, such advanced technology cannot be used for human alchemy, which is an absolute taboo in alchemy. However, the brothers Edward (voiced by Park Romi) and Alphonse (voiced by Kugimiya Rie), who have extremely high alchemy talents, are willing to violate taboos because of their great longing for their mother. The final price is that Edward lost an arm and a leg, and his younger brother Alphonse can only attach his soul to a huge armor. The two brothers who finally understood everything, in order to restore the original state and seek more alchemical knowledge, became national alchemists and embarked on a journey to find the ultimate alchemical item-the Philosopher's Stone. In the constant exploration, the two brothers finally discovered the truth behind the Philosopher's Stone and had a deeper understanding of the militarized country they were in. At this time, facing the country, nation, family... Where is the future of alchemy?