After lying dormant for 2 years, Dominic (Vin Diesel) and Brian (Paul Walker) teamed up again to steal the mysterious luxury car in the train, and were chased by the police and gangsters. Brian and Mia (Jordana Brewster) went to Rio to find reinforcements and met with Domi. In order to find the whereabouts of Domi and others, FBI ace agent Luke (Dwayne Johnson) stepped forward, formed an elite force, and tracked to Rio. He hired Elena (Elsa Pataky), a beautiful policewoman who had lost her husband, to find Domi together. At the same time, Rio's local snakes also opened fire on these uninvited guests. The three forces began to fight each other. During this period, because Mia was pregnant, Brian decided to flee with her, so Domi had to rely on his old friends to explore the secrets of the new car. With the help of Roman, Han and others, Domi finally found the secret of the car - the chip, and thus revealed an ulterior plan hidden in it...