Escobar (Wagner Moura) was once a smuggler. By chance, he started to get involved in the drug business. He was ambitious and sold countless drugs to the United States, becoming a drug lord who was rich enough to rival a country. At the same time, he assembled several giants in the circle and established the prestigious Medellin Group. For a time, Escobar's momentum was unmatched. Murphy (Boyd Holbrook) is a detective sent to Colombia by the US Drug Enforcement Administration. He and his partner Panna (Pedro Pascal) are mainly responsible for Escobar's case. Escobar became a congressman and even determined to run for president, but was publicly humiliated in Congress. After that, the Colombian government tried to use the extradition bill to deal with drug lords. In order to fight the government, Escobar completely became an antisocial terrorist. While constantly expanding his drug empire, he used bombs, assassinations and blood to remind the Colombian government who is the real boss.