When Gibson (Samuel L. Jackson), the founder of the TripleX project, is killed, NSA agent Marco (Toni Collette) decides to bring back Xander Cage (Vin Diesel), who has been tracked by the government since his fake death. In order to avenge Gibson, he agrees to return and recruits a new TripleX team, including sniper Adele Wolff (Ruby Rose), stunt driver Torch Tenison (Roy McCann), nightclub DJ Nix (Kris Wu), and computer analyst Becky (Nina Dobrev). The bad agents that Xander Cage's team targets include the leader Xiang (Donnie Yen), the deadly killer Selena Unger (Deepika Padukone), martial arts expert Taron (Tony Jaa), and weapons expert Hawk (Michael Bisping). But when the two teams meet, they suddenly find that things are not what they seem, and it is possible that the two groups have the same goals. At this moment, the two TripleX teams must work together to stop the unknown enemy.