After a series of family defense battles, former agent Brian Mills (Liam Neeson) now lives a seemingly peaceful life that is still turbulent: his daughter Kim (Maggie Grace) is pregnant but dares not tell him, and his ex-wife Lenore and her husband Stuart (Dougray Scott) do not live a perfect life, which makes her reconsider Brian, and Stuart goes to ask Brian to stop bothering Lenore... Soon, Brian is surprised to find that Lenore died in his bed. Brian, who is listed as the number one suspect by the police, can only rely on violence to get out and flee under the arrangement of Police Chief Dozelle (Forest Whitaker) in order to find out the real murderer. Soon, Brian discovers that the death of his ex-wife is related to Stuart's deal with the Russian mafia, and Kim may become the next victim...