As the leader of a secret government agency, Amanda (Viola Davis) faces an endless stream of violent terrorist attacks in society and is determined to use a group of super villains who are imprisoned and sentenced to life imprisonment. They are Harley Quinn (Margot Robbie), Deadshot (Will Smith), Captain Boomerang (Jai Courtney), Vengeance (Jay Hernandez) and Killer Croc (Adewale Akinnuoye-Agbaje). What they have to face is the powerful Enchantress (Cara Delevingne), who, together with her brother, has created a very dangerous weapon in an attempt to control all mankind. In addition, Amanda must also beware of the dangerous Joker (Jared Leto) who will do anything to save his girlfriend Harley Quinn.