A flight from Hamburg to Boston landed safely, but all the crew members and passengers on board died. This bizarre case opened the prelude to a series of strange and dangerous events. FBI agent Olivia Denham (Anna Torv) is shrewd and capable. She has just established a romantic relationship with her colleague John Scott (Mark Valley), but she lost her lover during an investigation. Olivia was subsequently recruited into the "Fringe Files Department" which specializes in bizarre cases. After that, various incredible events occurred one after another, and all signs indicated that all this seemed to be related to Dr. Walter Bishop (John Noble), known as the "contemporary Einstein" and the powerful and mysterious Juli Company. As the investigation deepened, the dark side and secrets behind the incident gradually emerged...