The greasy-mouthed mercenary Wade Wilson (played by Ryan Reynolds) meets the playful and cute Vanessa (played by Morena Baccarin), but at the happiest moment of love, he is diagnosed with advanced cancer, leaving little time in the world. In extreme desperation, he accepted the invitation of a private organization of Francis (played by Ed Skrein) to transform his genes in order to seek physical mutation. After enduring a series of cruel torture, Wade finally cured cancer and transformed into an immortal super soldier, but at the cost of losing the human face. The cunning Francis escaped, but Wade could not face his girlfriend with a horrible face. After that, he turned into a deadpool, shuttled through every dark corner, looking for Ajax...