Wade Wilson (Ryan Reynolds), the immortal deadpool, continues to run desperately on the road of punishing evil and promoting good, and his venomous tongue and mean mouth. At the same time, his love with his girlfriend Vanessa (Morena Baccarin) gradually sublimates, and the two look forward to the arrival of a new life. Who knows that fate is unpredictable. Because Vanessa died accidentally, Wade was desperate and desperately longed for the end of life. When he was most lost, Colossus and Juvenile Warhead took him away and became a member of the X-Men. In a certain operation, Deadpool was imprisoned in the ice box prison with Russell (Julian Dennison), a 14-year-old mutant who was out of control. Not long after, Cable (Josh Brolin) from the future broke into the prison, intending to kill Russell, who caused countless disasters in the future. In order to stop Cable, Deadpool, who escaped from prison, found a group of comrades to fight against him, while Russell gradually went away into the darkness...