The story takes place in the distant 26th century. The surgeon Ed (Christoph Waltz) picked up a mechanical girl with only her head left in the garbage dump and took her home. He installed a prosthetic body originally prepared for his late daughter and named her Alita (Rosa Salazar). After waking up, Alita became very interested in this colorful but violent and cruel world. After meeting the young man Hugo (Keean Johnson), Alita began to contact the sport called motorball and showed amazing fighting talent in the game. Above the heads of the residents of the scrap iron city, there is a huge floating city of Salem. All the labor and efforts of the residents of the scrap iron city are to provide Salem with fuel for continued operation. In the motorball competition set up by the big tycoon Victor (Mahershala Ali), the person who finally wins the championship can get the qualification to live in Salem. Alita decided to use her fighting talent to participate in the competition, but was involved in a huge conspiracy.