The film is adapted from the "Jungle Cruise" attraction in Disneyland. The story takes place in the early 20th century when ambitious people and explorers emerged together. The brave and fearless female scientist Dr. Lily Houghton (Emily Blunt) came to the Amazon to find a magical tree with healing powers, and hired the cynical Captain Frank (Dwayne Johnson) to start the expedition. During this epic adventure, the two seemingly incompatible people encountered countless dangers and supernatural forces in the dense rainforest. But as the secrets of this magical ancient tree are gradually revealed, the fate of Lily and Frank, and even the fate of all mankind, is at stake.