As humans become more and more adapted to synthetic environments, the human body begins to become an object of processing, ushering in new deformations. Saul Tenser (Viggo Mortensen) is a well-known performance artist. With the help of his assistant Caprice (Léa Seydoux), he begins to show the scenes of his organ deformation through some avant-garde performances. Timlin (Kristen Stewart), an investigator from the National Organ Registry, closely follows their every move. At this time, a mysterious organization appears, hoping to use Saul's reputation to show the world the next stage of human evolution...