Sun Yichen (played by Zhang Jicong) was imprisoned for his wrongful death when his female secretary was killed during a business trip. In prison, he not only had to deal with the prison bully Situ (played by Huang Guangliang), but also had to face the bullying of the cruel warden (played by Zheng Haonan). Only the prison guard Hu Hai (played by Zhang Jiansheng) reluctantly took care of him. The days in prison were already like years, and a deadly infectious disease also quietly arrived at this time. Faced with "natural disasters and man-made disasters", Yu Yichen decided to use his knowledge to change his fate and survive. How will he escape from danger and win a chance of survival?