Kanagawa New Airport is occupied by an armed group called "beasts" who cover their faces with masks. Musashi, who is involved in the incident again, asks for help from the manager Sakura Izumi, who has been on leave since the incident a year ago. Intelligence analyst Shima and new friends also join in to rescue the hostages from the airport and "eliminate" the "beasts" who are more dangerous than the "ghosts" in the previous game. On the other hand, Musashi's wife Yuko, a cardiologist who holds a scalpel at Yokohama Bay Hospital, is also involved in a certain incident. The deadline for rescuing the hostages is only one day. What are the true faces and purposes of the "beasts", and what is the fate of the Musashi family?