One is the vigorous, witty and humorous federal agent West (Will Smith), and the other is the clever disguise master Gordon (Kevin Kline). These two seemingly incompatible characters were summoned by the president at the same time because they were ordered to hunt down a mysterious and vicious scientist serial killer. West and Gordon had to develop a tacit understanding in the friction and collision, and soon became a perfect match. After investigation, the two found that the mastermind behind the scenes was the former genius Dr. Lovellis (Kenneth Branagh). He lost his legs in an experiment and had to stay in a wheelchair forever. However, his incomplete personality and resentment towards society made him start to make trouble everywhere, and even invented a giant spider machine to kill innocent people indiscriminately and attempted to murder the president and rule the United States. The crisis was imminent, and West and Gordon came to New Orleans separately, driving a train full of mechanisms to fight against Dr. Spider. A battle of wits and courage between strange weapons has quietly begun...