In the near future, the acquired myeloid sclerosis syndrome (ACIS), known as "Medusa", will spread all over the world. After an incubation period of 30 to 60 days, the infected will die in just 12 days. The whole body will be petrified when they die, and the appearance is terrifying. Since there is no specific medicine or confrontation method, the human world is in a doomsday panic. At this time, the scientific research and development company Venus Gate claims that it can preserve the hope of life for humans through cryosleep, but only 160 people in the world are eligible to enter the cryocapsule. The girl Isshiki Kasumi (voiced by Hanazawa Kana) is lucky to be one of the 160 people, but she will also be forced to part with her beloved twin sisters. When Xiaoxia wakes up again, she finds that the scene at the headquarters of Venus Gate is weird, and then a group of strange creatures attack these people. In the end, only a few people survived by chance. What a cruel fate will be waiting for Xiaoxia... This film is adapted from the original manga of the same name by Yuji Iwahara.